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Overall, the efficacy of semaglutide in weight reduction was demonstrated in patients both with concomitant T2Dspecifically in STEP 2 [39], which included only patients with T2D, as well as in STEP 6, 7, and 10, which included both patients with and without T2D [41,42,43]and without diabetes (STEP 1, 3, 4, 5, 8, and 9) [13, 38, 40, 44,45,46]

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A straight laser Doppler probe (outer diameter: 0.9 mm) was directed to the papilla between the two upper incisal teeth using manipulator fixation

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